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  1. Auscultation
    1. S2 heart sound
      1. intensity - increased
      2. splitting - in moderate conditions
      3. absence of A2 (single S2 from advanced stages of the disease)

    2. Murmur

      1. systolic ejection
        Note: increase / decrease in pitch as blood moves across aortic valve.

        note: the diamond shaped murmur located between S1 and S2 and also the increasing/decreasing intensity as ejection occurs
      2. ejection click (snapping of the leaflets as they open)

  2. Electrocardiographic Findings
    1. left ventricular enlargement - from LV hypertrophy
    2. left ventricular strain (high voltage)

    3. left axis deviation - from increased LV mass

  3. Echocardiographic Findings

    1. Aortic Valve

      1. 2D Echocardiography
        1. Thickened Aortic Leaflets
          2D parasternal long axis.
          Note: thickened leaflets
          ©atlantic interactive

          1. leaflet is more reflective and can be seen in systole and diastole
          2. best visualized in 2D
          3. right coronary cusp most affected
          4. left coronary cusp least affected
        2. Restricted Leaflet Motion
          1. systolic separation of right coronary cusp (anterior) and noncoronary cusp (posterior) falls below 1.5 cm in adults
          2. fused commissures results in systolic doming of the valve
        3. Narrowed orifice
          1. acquired - advanced valvular obstruction with calcification

            2D parasternal short axis of aortic valve. Note: reduced orifice size.
            ©atlantic interactive

          2. congenital – unicuspid or bicuspid aortic valve with/without calcification
            note: the eccentric separation of the aortic leaflets

            photo courtesy of Biosound Esaote

      2. M-mode
        1. Thickened Aortic Leaflets
          Note: thickened leaflets and decreased aortic cusp separation.
          ©atlantic interactive

        2. Eccentric opening possible in bicuspid aortic valve or in asymmetric commissural fusion.

      3. Spectral Doppler

        Patients with suspected aortic stenosis should have a thorough examination with continous wave Doppler.  It is important to evaluate the valve with the Pedoff probe from the apex and suprasternal notch, and also at the right sternal border with the patient in the right decubitus position.  The Pedoff, or "blind", transducer provides more accurate measurements because it doesn't share bandwidth with the imaging component of the "inline" transducer and may detect significantly higher gradients across the valve.
        1. Increased Peak Systolic Velocity - > 3.5 m/sec


        2. Note: Obtain maximal velocities in apical and suprasternal views

          ©atlantic interactive

        3. Increased Pressure Gradient (Bernoulli)
        4. Decreased Valve Orifice – Continuity Equation
          1. normal – 3 to 5cm2
          2. mild stenosis – 1.1 to 1.9 cm2
          3. moderate stenosis - .75 to 1.1 cm2
          4. severe stenosis - <.75 cm2

      4. Color Flow Doppler
        1. High velocity systolic jet

        2. ©atlantic interactive

        3. Jet may be eccentric

    2. Left Ventricle
      1. 2D Echocardiography
        1. Left Ventricular Hypertrophy - LV pressure overload syndrome


        2. ©atlantic interactive



          ©atlantic interactive

        3. Associated Mitral Valve Regurgitation

      2. M-Mode
        1. Increased thickness of septum and posterior wall
        2. Decreased fractional shortening in chronic aortic stenosis

    3. Aorta
      1. 2D Echocardiography
        1. Post Stenotic Dilatation of Aorta
        2. Possible presence of coarctation with bicuspid aortic valve
      2. Anatomy - altered valve profile in acuspid (no leaflets)

  4. Estimation of Severity
    1. Imaging
      1. direct measurement of aortic valve area in the parasternal short axis is difficult that with the mitral valve due to the smaller, more irregular and coarsely calcified valve. The aortic valve moves more rapidly through the scan plane than the mitral valve. The range from mild to severe stenosis is small (.25cm2).

      2. evaluation of leaflet motion as maximal aortic cusp separation (MACS) may be diminished when seen in the parasternal long axis view. Imaging should include the technique of "sweeping" through the scan plane to note valve irregularities. When MACS is <11mm, stenosis may be inferred as severe and valve surface area is ~.75cm2. Then MACS is >13mm, stenosis is considered to be mild with aortic valve surface area ~>1cm2.

    2. Doppler
      1. Peak Pressure Gradient - Use the Bernoulli equation:

        Beam should be parallel to blood flow so that the cosine theta angle should be no greater than 20 degrees to avoid underestimating the gradient. Seek the maximal velocity from apical, suprasternal, supraclavicular, left parasternal, right parasternal, and subcostal. Pressure gradients may be higher in patients with elevated cardiac output due to exercise, pregnancy, or acute anxiety states. Also, in patients with both aortic stenosis and aortic regurgitation, the augmentation of the forward stroke volume with the regurgitant volume will increase the pressure gradient.

      2. Mean Pressure Gradient – if instrument does not planimeter the gradient, you can use the manual method:


        ©atlantic interactive

      3. 1) measure the velocity of the envelope at equal spacing.
        2) square each velocity
        3) average the velocities by adding all of the values and dividing the number of values
        4) multiply value by 4 to get gradient in millimeters of mercury.

      4. Aortic Valve Area - use the Continuity Equation to determine the aortic valve surface area in cm2.

        AVA = CSA(LVOT) * (Vmax LVOT) / (Vmax AV)

        Steps in Determining the values:

        1) measure the LVOT diameter just below the aortic valve in the parasternal long axis view.
        2) Calculate the CSA : CSA=.785(D2)
        3) Measure the velocity of the LVOT with PW Doppler from the apical 5 chamber to the maximal velocity just beyond the Aortic Valve.
        4) Measure the velocity of the LVOT with CW Doppler from the apical, suprasternal, supraclavicular, left parasternal, right parasternal, and subcostal positions

      5. Normal Aortic Doppler Values

          peak velocity valve surface area
        Normal 1.35m/s (1.0 to 1.7) 2-4cm2
        Mild <3.5m/s >1cm2
        Moderate 3.5m/s to 4.0m/s .75-1cm2
        Severe >4.0m/s <.75cm2

      6. Differential Diagnosis in Patients with both AS and MR – the aortic Doppler envelope occurs later and ends earlier than the envelope of mitral regurgitation. Also, the peak velocity of mitral regurgitation is always higher than that for aortic stenosis.
  1. Cardiac Catheterization
    1. Pressure Data
      1. Left Ventricular Pressure
        1. Elevated left ventricular pressure occurs due to the greater effort of the ventricle to force blood through the narrowed opening of the aortic valve.
        2. Elevated end diastolic pressure may occur as ventricle adapts to the pressure overload condition.
      2. Left Atrial Pressure
        1. Elevated left atrial pressure increases as atrium adapts to changes in left ventricular pressures.
        2. Prolonged elevated left ventricular pressures may cause mitral regurgitation.
      3. Aortic Valve Gradient
        1. Peak to peak pressure gradient is calculated by measuring the peak left ventricular systolic pressure minus the peak aortic systolic pressure. This illustration shows an LV-to-AO pullback recording of the change in pressure across the valve.


          ©atlantic interactive

        2. Mean gradient is typically calculated by computer analysis of the pressure differences between the interior of the left ventricle and the aorta at the aortic root position by using the "area under the curve" method.

          ©atlantic interactive

    2. Angiographic Data
      1. poststenotic dilatation of the aorta
      2. calcified aortic ring
      3. narrowed orifice
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